Multiplicity of microbiota species is characteristic of the GI microbiome in healthy individuals, and a loss in species has adverse effects. Dietary diversity and taking a variety of probiotic species and strains are methods that help support a healthy microbiome. ProbioMax 350 DF provides
18 different strains belonging to 13 different species of three different genera. The HOWARU and FloraFIT strains that comprise these formulas are stable, proven, and trusted worldwide.

Featured Strains: Bifidobacterium lactis HN019® and Lactobacillus rhamnosus HN001®
B lactis HN019® and L rhamnosus HN001® have been studied extensively in vitro and in vivo (in animals and humans) to establish beneficial effects and safety. In human research, B lactis HN019® significantly decreased mean whole-gut transit time in adults compared to placebo. Supplementation also had a positive effect on functional GI symptoms, as were self-reported by patient surveys. In a randomized, double-blind, placebo-controlled human dietary intervention study in subjects 60 or more years of age, supplementary HN019® resulted in desirable changes in the intestinal microflora, including significant increases in bifidobacteria and lactobacilli. HN019® has also shown promising effects on parameters of cardiovascular and metabolic health. Compared with baseline and control group values, individuals taking 27 billion CFU had a significant reduction in body mass index, significant improvements in cholesterol and low-density lipoprotein metabolism, and significant decreases in tumor necrosis factor-alpha and interleukin-6. In a three-week study, individuals consuming low-fat/low-lactose milk supplemented with HN019® or HN001® showed increased immune activity when compared to a milk-alone run in. These increases were significantly correlated with age; that is, subjects older than 70 years experienced significantly greater improvements than those under 70 years. Researchers suggest that these results demonstrate the ability of HN019® and HN001® to combat some of the deleterious effects of immunosenescence on cellular immunity. Animal studies demonstrate the ability of HN001® to support natural and acquired immunity as well as promote resistance. More recently, human studies have demonstrated HN001®’s protective effect on skin health in genetically susceptible individuals.

Other strains:

• Cause the development of inhibition zones around Clostridium difficile, Salmonella typhimurium, Staphylococcus aureus, Escherichia coli, and Listeria monocytogenes in agar assays 
• Populate vaginal tissue
• Induce moderate maturation and activation of dendritic cells
• Degrade oxalates
• Increase IgA and IgG responses
• Reduce levels of E coli and enterococcus after antibiotic therapy
• Help increase and recover numbers of intestinal lactobacilli and/or bifidobacteria
• Promote well-being in relation to intestinal cytokine production
• Improve gastrointestinal health and well-being when under challenge
• Help maintain upper respiratory health
• Alter the fecal microbiota in obese subjects
• Maintain healthy fluid balance and integrity of intestinal wall
• Support intestinal barrier function

Competitive Inhibition – The ability of probiotics to maintain a healthy microbial balance in the gut is unquestionably important to its usefulness. Probiotics produce inhibitory compounds that limit the growth of other organisms, they compete with other organisms for adhesion sites and nutrients, and they inhibit the production of toxins, among other actions.

Cytokine and Immune Modulation – Microbiota are key elements in the body’s defense system. Cytokines regulate immune system function, and the included strains have demonstrated the ability to upregulate or downregulate various cytokines.

Antibiotic Resistance – Antibiotic susceptibility patterns are an important means of indicating the potential of an organism to be readily inactivated by antibiotics used in human therapy. Importantly, acquired antibiotic resistance or antibiotic resistance transfer have not been detected in any of these strains.

» Supports a Healthy Microbiome
» Replenishes Good Bacteria in the Gut
» Supports the Natural Immune Response
» Supports Lactose Digestion
» Supports Bowel Regularity

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.