Clinically Studied, Safe Butterbur

Butterbur Without PA’s (pyrrolizidine alkaloids)

Standardized Botanical Butterbur Formula, Evidence-Based Efficacy

The American Academy of Neurology (AAN) evidence-based guideline states: there is strong evidence (Level A) that petasites (butterbur) is established as effective and should be offered for migraine prevention.

Petadolex is the only brand of butterbur root extract that has been used in clinical trials and the only butterbur root extract that uses a patented manufacturing process to remove PA’s that occur naturally in butterbur.

After 3 months on Petadolex (75 mg twice daily)– 71% of adults experienced a reduction in migraine attacks by 50% or more, as demonstrated in clinical studies published in peer-reviewed medical journals.

Petadolex works by helping to maintain smooth muscle tone in cerebral blood vessels, and through its anti-inflammatory and analgesic (pain-relieving) properties. On a chemical level, its active ingredients petasin and isopetasin, inhibit the synthesis of both inflammatory leukotrienes (LOX) and COX-2 enzymes.

However, Petadolex does not produce relief immediately; it has to build up in your body’s system (it may take up to 3 months) to experience maximum benefits.

Nonetheless, clinical trials have shown that even after 4 weeks on Petadolex (150 mg/day), 54% of adults experienced a 50% reduction in migraine attacks (frequency and migraine pain).

While the natural whole plant form of Buttterbur contains pyrrolizidine alkaloids or PAs, these toxic compounds are all removed in the Petadolex manufacturing process.

Weber & Weber cultivates and processes their own butterbur plants using their patented process that extracts and purifies the active ingredient of butterbur — petasin. Petadolex is at least 15% petasin extract.

Ingredients:

Petasin and Isopetasin (75mg Purple Butterbur root extract, standardized to at least 15%)

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.