Manganese supports numerous enzymes necessary for the utilization of biotin, thiamine, and ascorbic acid. It is a catalyst in the synthesis of fatty acids and cholesterol, and plays a part in protein, carbohydrate, and fat production. It is also a necessary cofactor for the endogenous antioxidant superoxide dismutase. Manganese is necessary for normal skeletal development and maintenance of connective tissue and cellular integrity. In addition, it influences the synthesis of mucopolysaccharides, which comprise an important component of connective tissue.